Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase.

de Beer, Johannie; Petzer, Jacobus P; Lourens, Anna C U; Petzer, Anél

de Beer, Johannie; Petzer, Jacobus P; Lourens, Anna C U; Petzer, Anél.

Afiliação

de Beer J; Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
Petzer JP; Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
Lourens ACU; Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
Petzer A; Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

Mol Divers ; 25(2): 753-762, 2021 May.

Article em En | MEDLINE | ID: mdl-32108308

Assuntos

Inibidores de Catecol O-Metiltransferase; Piridinas; Animais; Catecol O-Metiltransferase/química; Inibidores de Catecol O-Metiltransferase/síntese química; Inibidores de Catecol O-Metiltransferase/química; Desenho de Fármacos; Fígado/enzimologia; Modelos Moleculares; Piridinas/síntese química; Piridinas/química; Suínos

Palavras-chave

3-Hydroxypyridin-4-one; COMT; Catechol-O-methyltransferase; Inhibition; Parkinson's disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Catecol O-Metiltransferase Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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