Anti-inflammatory labdane diterpenoids from Leonurus japonicus Houtt.
Phytochemistry
; 173: 112223, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32113063
ABSTRACT
Seven undescribed labdane diterpenoids, japonicones A-G, were isolated from the aerial parts of Leonurus japonicus Houtt. Japonicones C-G contained two keto carbonyl groups in their structures attached to C-3 and C-7, which are rare for labdane diterpenoids. The structures and absolute configurations of japonicones A-G were established by means of spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ECD). Their anti-inflammatory activities were evaluated by measuring their inhibitory effects on PGE2 production in LPS-stimulated RAW264.7 macrophages. Japonicones A-D and G showed inhibition of PGE2 production with IC50 values in the range of 8.62-30.71 µM (the positive control paracetamol showed an IC50 = 5.79 µM).
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Base de dados:
MEDLINE
Assunto principal:
Leonurus
/
Diterpenos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article