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Novel androgen receptor antagonist identified by structure-based virtual screening, structural optimization, and biological evaluation.
Tang, Qin; Fu, Weitao; Zhang, Minkui; Wang, Ercheng; Shan, Lvhu; Chai, Xin; Pang, Jinping; Wang, Xuwen; Xu, Xiaohong; Xu, Lei; Li, Dan; Sheng, Rong; Hou, Tingjun.
Afiliação
  • Tang Q; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Fu W; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Zhang M; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Wang E; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Shan L; Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
  • Chai X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Pang J; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Wang X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
  • Xu X; Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
  • Xu L; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, 213001, Jiangsu, China.
  • Li D; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address: lidancps@zju.edu.cn.
  • Sheng R; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address: shengrong1973@163.com.
  • Hou T; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, China. Electronic address: tingjunhou@zju.edu.cn.
Eur J Med Chem ; 192: 112156, 2020 Apr 15.
Article em En | MEDLINE | ID: mdl-32114360
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolonas / Antagonistas de Receptores de Andrógenos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolonas / Antagonistas de Receptores de Andrógenos Idioma: En Ano de publicação: 2020 Tipo de documento: Article