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IgG4-type Multiple Myeloma with Diffuse Enlargement of the Thyroid Requiring Differentiation from IgG4-related Disease.
Funada, Masashi; Nakano, Kazuhisa; Miyata, Hiroko; Nawata, Aya; Tanaka, Yoshiya.
Afiliação
  • Funada M; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • Nakano K; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • Miyata H; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
  • Nawata A; The Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Japan.
  • Tanaka Y; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Intern Med ; 59(5): 711-714, 2020.
Article em En | MEDLINE | ID: mdl-32115519
We herein report a 65-year-old man with elevated serum IgG4 levels, enlarged thyroid, and renal dysfunction, mimicking IgG4-related disease (IgG4-RD). The definitive diagnosis of IgG4-RD was not established because a tissue biopsy revealed no IgG4-positive cell infiltration or fibrosis. The presence of an M peak in the ß fraction, Bence Jones protein in urine, and progressive anemia suggested multiple myeloma (MM). The κ/λ ratio was >100, tumor plasma cells were present at >20% in bone marrow, and immunostaining revealed IgG4-positive plasma cells; therefore, he was diagnosed with IgG4-type MM. Patients with elevated IgG4 levels with no significant mass lesions should undergo systemic examinations to exclude malignancy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Doença Relacionada a Imunoglobulina G4 / Mieloma Múltiplo Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Doença Relacionada a Imunoglobulina G4 / Mieloma Múltiplo Idioma: En Ano de publicação: 2020 Tipo de documento: Article