IgG4-type Multiple Myeloma with Diffuse Enlargement of the Thyroid Requiring Differentiation from IgG4-related Disease.
Intern Med
; 59(5): 711-714, 2020.
Article
em En
| MEDLINE
| ID: mdl-32115519
We herein report a 65-year-old man with elevated serum IgG4 levels, enlarged thyroid, and renal dysfunction, mimicking IgG4-related disease (IgG4-RD). The definitive diagnosis of IgG4-RD was not established because a tissue biopsy revealed no IgG4-positive cell infiltration or fibrosis. The presence of an M peak in the ß fraction, Bence Jones protein in urine, and progressive anemia suggested multiple myeloma (MM). The κ/λ ratio was >100, tumor plasma cells were present at >20% in bone marrow, and immunostaining revealed IgG4-positive plasma cells; therefore, he was diagnosed with IgG4-type MM. Patients with elevated IgG4 levels with no significant mass lesions should undergo systemic examinations to exclude malignancy.
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MEDLINE
Assunto principal:
Glândula Tireoide
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Doença Relacionada a Imunoglobulina G4
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Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article