A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.

Liu, Ming; Yan, Qian; Sun, Yi; Nam, Yoonhee; Hu, Liang; Loong, Jane Hc; Ouyang, Qi; Zhang, Yu; Li, Hao-Long; Kong, Fan-En; Li, Lei; Li, Yan; Li, Mei-Mei; Cheng, Wei; Jiang, Ling-Xi; Fang, Shuo; Yang, Xiao-Dong; Mo, Jia-Qiang; Gong, Yuan-Feng; Tang, Yun-Qiang; Li, Yan; Yuan, Yun-Fei; Ma, Ning-Fang; Lin, Ge; Ma, Stephanie; Wang, Ji-Guang; Guan, Xin-Yuan

Liu, Ming; Yan, Qian; Sun, Yi; Nam, Yoonhee; Hu, Liang; Loong, Jane Hc; Ouyang, Qi; Zhang, Yu; Li, Hao-Long; Kong, Fan-En; Li, Lei; Li, Yan; Li, Mei-Mei; Cheng, Wei; Jiang, Ling-Xi; Fang, Shuo; Yang, Xiao-Dong; Mo, Jia-Qiang; Gong, Yuan-Feng; Tang, Yun-Qiang; Li, Yan; Yuan, Yun-Fei; Ma, Ning-Fang; Lin, Ge; Ma, Stephanie; Wang, Ji-Guang; Guan, Xin-Yuan.

Afiliação

Liu M; Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, 510095 Guangzhou, China; liuming@gzhmu.edu.cn xyguan@hku.hk.
Yan Q; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 510120 Guangzhou, China.
Sun Y; Department of Clinical Oncology, Center for Cancer Research; State Key Laboratory for Liver Research, University of Hong Kong, 852 Hong Kong.
Nam Y; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, 410000 Changsha, China.
Hu L; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, National Engineering and Research Center of Human Stem Cell, Central South University, 410000 Changsha, China.
Loong JH; Division of Life Science, Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, 852 Hong Kong.
Ouyang Q; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, 410000 Changsha, China.
Zhang Y; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, National Engineering and Research Center of Human Stem Cell, Central South University, 410000 Changsha, China.
Li HL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 852 Hong Kong.
Kong FE; State Key Laboratory of Liver Research, The University of Hong Kong, 852 Hong Kong.
Li L; Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, 410000 Changsha, China.
Li Y; Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, National Engineering and Research Center of Human Stem Cell, Central South University, 410000 Changsha, China.
Li MM; Department of Clinical Oncology, Center for Cancer Research; State Key Laboratory for Liver Research, University of Hong Kong, 852 Hong Kong.
Cheng W; Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, 510095 Guangzhou, China.
Jiang LX; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 510120 Guangzhou, China.
Fang S; Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, 510095 Guangzhou, China.
Yang XD; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 510120 Guangzhou, China.
Mo JQ; Department of Clinical Oncology, Center for Cancer Research; State Key Laboratory for Liver Research, University of Hong Kong, 852 Hong Kong.
Gong YF; Department of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Southern University of Science and Technology, Shenzhen 518055, China.
Tang YQ; Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, 510095 Guangzhou, China.
Li Y; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 510120 Guangzhou, China.
Yuan YF; Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, 510095 Guangzhou, China.
Ma NF; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, 510120 Guangzhou, China.
Lin G; Shanghai Key Laboratory of Gastric Neoplasms, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200000 Shanghai, China.
Ma S; Department of Clinical Oncology, Center for Cancer Research; State Key Laboratory for Liver Research, University of Hong Kong, 852 Hong Kong.
Wang JG; Department of Clinical Oncology, Center for Cancer Research; State Key Laboratory for Liver Research, University of Hong Kong, 852 Hong Kong.
Guan XY; Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 510000 Guangzhou, China.

Proc Natl Acad Sci U S A ; 117(11): 6103-6113, 2020 03 17.

Article em En | MEDLINE | ID: mdl-32123069

Assuntos

Biomarcadores Tumorais/metabolismo; Carcinoma Hepatocelular/genética; Regulação da Expressão Gênica no Desenvolvimento; Regulação Neoplásica da Expressão Gênica; Hepatócitos/patologia; Neoplasias Hepáticas/genética; Aminopiridinas/farmacologia; Aminopiridinas/uso terapêutico; Animais; Biomarcadores Tumorais/antagonistas & inibidores; Carcinoma Hepatocelular/mortalidade; Carcinoma Hepatocelular/patologia; Carcinoma Hepatocelular/cirurgia; Diferenciação Celular/efeitos dos fármacos; Diferenciação Celular/genética; Linhagem Celular; Transformação Celular Neoplásica/efeitos dos fármacos; Transformação Celular Neoplásica/genética; Estudos de Coortes; Intervalo Livre de Doença; Fator de Transcrição E2F1/antagonistas & inibidores; Fator de Transcrição E2F1/metabolismo; Feminino; Perfilação da Expressão Gênica; Hepatectomia; Células-Tronco Embrionárias Humanas; Humanos; Hidroxiquinolinas/farmacologia; Hidroxiquinolinas/uso terapêutico; Isoquinolinas/farmacologia; Isoquinolinas/uso terapêutico; Estimativa de Kaplan-Meier; Fígado/crescimento & desenvolvimento; Fígado/patologia; Fígado/cirurgia; Neoplasias Hepáticas/mortalidade; Neoplasias Hepáticas/patologia; Neoplasias Hepáticas/cirurgia; Masculino; Camundongos; Pessoa de Meia-Idade; Prognóstico; Piridinas/farmacologia; Piridinas/uso terapêutico; Pirróis/farmacologia; Pirróis/uso terapêutico; Transdução de Sinais/genética; Proteína Smad3/antagonistas & inibidores; Proteína Smad3/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

cancer subtype; hepatocyte differentiation; liver development; oncofetal properties; oncogenic driver

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Regulação da Expressão Gênica no Desenvolvimento / Hepatócitos / Neoplasias Hepáticas Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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