Persistence of symptoms in dengue patients: a clinical cohort study.
Trans R Soc Trop Med Hyg
; 114(5): 355-364, 2020 05 07.
Article
em En
| MEDLINE
| ID: mdl-32125417
ABSTRACT
BACKGROUND:
Dengue is commonly considered an acute illness and follows three phases febrile, critical in some cases and recovery. However, a number of studies have described a continuation of dengue symptoms for weeks or months, extending the recovery phase. Here we evaluate this persistence of dengue symptoms during convalescence.METHODS:
Our clinical cohort study included patients who sought medical services 48 to 144 h from the onset of fever at seven hospitals or ambulatory centers in Morelos, Mexico. Seventy-nine laboratory-confirmed dengue patients were followed up regularly using clinic and/or home visits and telephone calls for as long as symptoms persisted or up to 6 mo.RESULTS:
In total, 55.7% of patients had dengue-related symptoms 1 mo after the onset of fever; pain and dermatological manifestations were the most common persistent symptoms. Prognostic factors for symptom persistence were ≥4 d of fever (RR 1.72; 95% CI 1.35 to 2.19), platelet count ≤100 000/mm3 (RR 1.20; 95% CI 1.20 to 2.20), petechiae/bruises (RR 1.97; 95% CI 1.56 to 2.48) and abdominal pain/hepatomegaly (RR 1.79; 95% CI 1.41 to 2.28).CONCLUSIONS:
Persistence of dengue symptoms were common in laboratory-confirmed dengue patients. Manifestations related to tissue damage were associated with persistence after 30 d; host characteristics, such as age and health status before infection, were associated with prolonged persistence (>60 d). The burden of dengue may be higher than previously estimated.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Dengue
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article