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Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021.
Ouchi, Takahito; Watanabe, Yoshihiro; Nonaka, Kenichi; Muramatsu, Reiko; Noguchi, Chikako; Tozawa, Miho; Hokari, Rei; Ishiyama, Aki; Koike, Rima; Matsui, Hidehito; Asami, Yukihiro; Inahashi, Yuki; Ishii, Takahiro; Teruya, Toshiaki; Iwatsuki, Masato; Hanaki, Hideaki; Omura, Satoshi.
Afiliação
  • Ouchi T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Watanabe Y; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Nonaka K; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Muramatsu R; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Noguchi C; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Tozawa M; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Hokari R; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Ishiyama A; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Koike R; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Matsui H; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Asami Y; Graduate School of Science, Kitasato University, 1-15-1, Kitazato, Minami, Sagamihara, Kanagawa, 252-0373, Japan.
  • Inahashi Y; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Ishii T; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Teruya T; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Iwatsuki M; Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Hanaki H; Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
  • Omura S; Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa, 903-0213, Japan.
J Antibiot (Tokyo) ; 73(6): 365-371, 2020 06.
Article em En | MEDLINE | ID: mdl-32139881
ABSTRACT
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Ácidos Hidroxâmicos / Hypocreales / Antimaláricos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Ácidos Hidroxâmicos / Hypocreales / Antimaláricos Idioma: En Ano de publicação: 2020 Tipo de documento: Article