[Is hypoxia a factor in the progression of pulmonary sarcoidosis?] / L'hypoxie est-elle un facteur impactant l'évolution de la sarcoïdose pulmonaire ?
Rev Mal Respir
; 37(3): 214-217, 2020 Mar.
Article
em Fr
| MEDLINE
| ID: mdl-32146058
ABSTRACT
Sarcoidosis is a systemic granulomatous disease that can reduce life expectancy mainly due to pulmonary fibrosis resulting from granulomatous inflammation The lack of vascularization within pulmonary granulomas suggests that macrophages localized in the center of these structures are hypoxic. Hypoxia signaling pathways are known to be pro-inflammatory and pro-fibrotic in various pathological conditions. Recent data suggest an involvement of the transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of sarcoidosis. This could represent a new research approach for the understanding and therapeutic management of sarcoidosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sarcoidose Pulmonar
/
Hipóxia
Idioma:
Fr
Ano de publicação:
2020
Tipo de documento:
Article