Cytochemical Evaluation of the Toxic Effects of Combined Antituberculosis Substances on Metabolic State of Blood Lymphocytes.
Bull Exp Biol Med
; 168(4): 470-473, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-32146623
ABSTRACT
Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Protionamida
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Pirazinamida
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Rifampina
/
Linfócitos
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Fluoroquinolonas
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Etambutol
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Isoniazida
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Antituberculosos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article