Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings.

Choi, Min-Koo; Jin, Sojeong; Jeon, Ji-Hyeon; Kang, Woo Youl; Seong, Sook Jin; Yoon, Young-Ran; Han, Yong-Hae; Song, Im-Sook

Choi, Min-Koo; Jin, Sojeong; Jeon, Ji-Hyeon; Kang, Woo Youl; Seong, Sook Jin; Yoon, Young-Ran; Han, Yong-Hae; Song, Im-Sook.

Afiliação

Choi MK; College of Pharmacy, Dankook University, Cheon-an, Republic of Korea.
Jin S; College of Pharmacy, Dankook University, Cheon-an, Republic of Korea.
Jeon JH; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.
Kang WY; Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea.
Seong SJ; Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Yoon YR; Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Graduate School, Kyungpook National University, Daegu, Republic of Korea.
Han YH; Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea.
Song IS; Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Graduate School, Kyungpook National University, Daegu, Republic of Korea.

J Ginseng Res ; 44(2): 229-237, 2020 Mar.

Article em En | MEDLINE | ID: mdl-32148404

Palavras-chave

Hank's balanced salt solution, HBSS; MRT, mean residence time; apical to basal, A to B; apparent permeability, Papp; area under the plasma concentration-time curve, AUC; basal to apical, B to A; ginsenosides; liquid chromatography-tandem mass spectrometry, LC-MS/MS; maximum plasma concentration, Cmax; multiple reaction monitoring, MRM; pharmacokinetics; red ginseng; single and repeated administration; t1/2, elimination half-life; time to reach Cmax, Tmax; tolerability

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article