Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells.
Cold Spring Harb Perspect Med
; 11(3)2021 03 01.
Article
em En
| MEDLINE
| ID: mdl-32152246
ABSTRACT
Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-origin and molecular phenotypes. We review how lymphomas arise throughout the B-cell development process as well as the molecular and clinical features of prominent B-cell lymphomas. We provide an overview of the major progress that has occurred over the past decade in terms of our molecular understanding of these diseases. We discuss treatment options available and focus on a number of the diverse research tools that have been employed to improve our understanding of these diseases. We discuss the problem of heterogeneity in lymphomas and anticipate that the near future will bring significant advances that provide a measurable impact on NHL outcomes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfoma não Hodgkin
/
Linfócitos B
/
Linfoma de Células B
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article