Preparation of Spray-Dried Nanoparticles for Efficient Drug Delivery to the Lungs.
Methods Mol Biol
; 2118: 139-145, 2020.
Article
em En
| MEDLINE
| ID: mdl-32152976
ABSTRACT
The use of nanoparticulate systems for pulmonary drug delivery offers a number of advantages including significantly improved delivery efficiency to deep lung and the improved bioavailability. The traditional nanoparticle manufacturing process such as ball/jet milling often yields large aggregates, which could detrimentally inhibit the effective delivery of drug particles to the lower respiratory tract. Here we report an alternative technique of spray-drying the microemulsions to produce nanoparticles (<100 nm) that can be dispersed homogenously in the propellant to form an extremely stable pressurized metered-dose inhaler (pMDI) formulations. Such nanoparticulate formulations provide an ideal tool for pulmonary drug delivery.
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Base de dados:
MEDLINE
Assunto principal:
Composição de Medicamentos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article