The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques.
Chem Commun (Camb)
; 56(28): 4015-4018, 2020 Apr 11.
Article
em En
| MEDLINE
| ID: mdl-32159532
ABSTRACT
Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Nanoestruturas
/
Bicamadas Lipídicas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article