First case of Abiotophia defectiva infectious endocarditis treated with a combination of amoxicillin and daptomycin.
J Chemother
; 32(6): 323-325, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32162586
ABSTRACT
Abiotophia defectiva (A. defectiva) infectious endocarditis (IE) is a serious disease that usually requires lengthy treatment with a combination of amoxicillin and gentamicin. Since severe nephrotoxicity can be associated with prolonged administration of gentamicin, the alternative use of daptomycin in combination with amoxicillin can be considered. We present the case of a 51-year-old man that presented an A. defectiva endocarditis on an aortic bicuspidy. Diagnosis of cirrhosis was made simultaneously, and therefore gentamicin was counter-indicated. A combination of amoxicillin 12 g per day and daptomycin 700 mg (10 mg/kg) was administrated, with resolution of clinical, biological and echographic abnormalities, and no relapse after 1 year. In our experience, amoxicillin with daptomycin could be an alternative in case of A. defectiva IE with counter-indication to aminoglycosides.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Bactérias Gram-Positivas
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Daptomicina
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Endocardite Bacteriana
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Abiotrophia
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Amoxicilina
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Antibacterianos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article