Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma.
Cancer Sci
; 111(5): 1491-1499, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32167621
ABSTRACT
Human leukocyte antigen (HLA) class â
molecules play a central role in anticancer immunity, but their prognostic value in oral squamous cell carcinoma (OSCC) remains unclear. We examined HLA class I expression in 2 distinct tumor compartments, namely, the tumor center and invasive front, and evaluated the association between its expression pattern and histopathological status in 137 cases with OSCC. Human leukocyte antigen class â
expression was graded semiquantitatively as high, low, and negative. At the invasive front of the tumor, HLA class I expression was high in 72 cases (52.6%), low in 44 cases (32.1%), and negative in 21 cases (15.3%). The HLA class I expression in the tumor center was high in 48 cases (35.0%), low in 58 cases (42.4%), and negative in 31 cases (22.6%). The 5-year overall survival and disease-specific survival rates were good in cases with high HLA class I expression at the invasive front; however, there was no significant difference in survival based on HLA class I expression in the tumor center. In addition, high HLA class I expression was correlated with high CD8+ T cell density, whereas negative HLA class I expression was correlated with low CD8+ T cell density at the invasive front. These results suggest that it is easier for CD8+ T cells to recognize presented peptides in the case of high HLA class â
expression at the tumor invasive front and could be a prognostic factor for OSCC.
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MEDLINE
Assunto principal:
Neoplasias Bucais
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Carcinoma de Células Escamosas
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Antígenos de Histocompatibilidade Classe I
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Regulação Neoplásica da Expressão Gênica
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article