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Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Lin, Shu-Yu; Chang, Chun-Feng; Coumar, Mohane Selvaraj; Chen, Pei-Yi; Kuo, Fu-Ming; Chen, Chun-Hwa; Li, Mu-Chun; Lin, Wen-Hsing; Kuo, Po-Chu; Wang, Sing-Yi; Li, An-Siou; Lin, Chin-Yu; Yang, Chen-Ming; Yeh, Teng-Kuang; Song, Jen-Shin; Hsu, John T A; Hsieh, Hsing-Pang.
Afiliação
  • Lin SY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Chang CF; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Coumar MS; Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India.
  • Chen PY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Kuo FM; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Chen CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Li MC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Lin WH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Kuo PC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Wang SY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Li AS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Lin CY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Yang CM; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Yeh TK; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Song JS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Hsu JTA; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC.
  • Hsieh HP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan, ROC; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC; Frontier Research Center on Fundamental and Applied Sciences of Ma
Bioorg Chem ; 98: 103689, 2020 05.
Article em En | MEDLINE | ID: mdl-32171993
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Aurora Quinases / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Inibidores de Proteínas Quinases / Descoberta de Drogas / Aurora Quinases / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article