Unconventional Secondary Structure Mimics: Ladder-Rungs.
Angew Chem Int Ed Engl
; 59(24): 9398-9402, 2020 06 08.
Article
em En
| MEDLINE
| ID: mdl-32176815
ABSTRACT
Secondary structures tend to be recognizable because they have repeating structural motifs, but mimicry of these does not have to follow such well-defined patterns. Bioinformatics studies to match side-chain orientations of a novel hydantoin triazole chemotype (1) to protein-protein interfaces revealed it tends to align well across parallel and antiparallel sheets, like rungs on a ladder. One set of these overlays was observed for the protein-protein interaction uPAâ
uPAR. Consequently, chemotype 1 was made with appropriate side-chains to mimic uPA at this interface. Biophysical assays indicate these compounds did in fact bind uPAR, and elicit cellular responses that affected invasion, migration, and wound healing.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Materiais Biomiméticos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article