Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2.

Zhang, Ruo-Yu; Yu, Zhi-Hong; Chen, Lan; Walls, Chad D; Zhang, Sheng; Wu, Li; Zhang, Zhong-Yin

Zhang, Ruo-Yu; Yu, Zhi-Hong; Chen, Lan; Walls, Chad D; Zhang, Sheng; Wu, Li; Zhang, Zhong-Yin.

Afiliação

Zhang RY; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Yu ZH; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Chen L; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Walls CD; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Zhang S; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Wu L; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907.
Zhang ZY; Departments of Medicinal Chemistry and Molecular Pharmacology and of Chemistry, Center for Cancer Research, and Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907. Electronic address: zhang-zy@purdue.edu.

J Biol Chem ; 295(18): 6187-6201, 2020 05 01.

Article em En | MEDLINE | ID: mdl-32188694

Assuntos

Substituição de Aminoácidos; Proteína Tirosina Fosfatase não Receptora Tipo 11/genética; Sequência de Aminoácidos; Domínio Catalítico; Cristalografia por Raios X; Humanos; Modelos Moleculares; Proteína Tirosina Fosfatase não Receptora Tipo 11/química; Proteína Tirosina Fosfatase não Receptora Tipo 11/metabolismo

Palavras-chave

SHP2; cancer; kinetics; mutation; phosphatase; signaling; structurefunction; transformation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substituição de Aminoácidos / Proteína Tirosina Fosfatase não Receptora Tipo 11 Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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