Cerebral Amyloid Angiopathy: A Clinico-Radiological Study from South India.
Neurol India
; 68(2): 378-382, 2020.
Article
em En
| MEDLINE
| ID: mdl-32189707
ABSTRACT
INTRODUCTION:
Cerebral amyloid angiopathy (CAA) is a major cause of intracerebral hemorrhage (ICH) and cognitive decline in the elderly. Since it is rarely reported from the developing world, we looked into the clinical profile and neuroimaging associations of CAA. MATERIALS ANDMETHODS:
Ours was a retrospective case series of subjects diagnosed with probable/possible CAA between January 2006 and December 2015 as per Boston criteria. Clinical profile and neuroimaging were reviewed for markers of CAA. Details of any recurrent clinical events and functional status were collected from follow-up records.RESULTS:
We had 28 subjects in the series with men outnumbering women, and the mean age was 70.17 ± 8.85 years (55-87 years). At the initial presentation, ICH was most frequent-10/28 (35.7%) patients, followed by transient neurological events (TNE = 25%) and cognitive disturbances (21.4%). Less than half of the patients received a diagnosis of CAA at the initial presentation itself. In total, 68% of our patients had cognitive dysfunction at admission. In our series, 12 had seizures and 9 had a history of TNE. The majority of our patients had vascular risk factors also. Leukoaraiosis showed an association with cognitive dysfunction (P = 0.044). Superficial siderosis and subarachnoid hemorrhage (SAH) showed a positive association with seizures and TNE, respectively. However, ICH showed no association with risk factors or imaging markers of CAA.CONCLUSIONS:
CAA patients, with a high prevalence of vascular risk factors mostly presented with ICH. The presence of SAH and superficial siderosis on MRI was associated with presentation as TNE and seizures, respectively.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Convulsões
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Hemorragia Subaracnóidea
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Hemorragia Cerebral
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Angiopatia Amiloide Cerebral
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Leucoaraiose
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Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article