Diabetic versus non-diabetic rhino-orbito-cerebral mucormycosis.
Mycoses
; 63(6): 573-578, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32191363
ABSTRACT
OBJECTIVE:
To compare the characteristics and outcomes of rhino-orbito-cerebral mucormycosis (ROCM) in diabetic versus non-diabetic patients.METHOD:
It is a retrospective comparative case series on consecutive patients with biopsy-proven ROCM. Systemic and ophthalmic manifestations, imaging, management and final outcomes were compared between diabetic versus non-diabetic ROCMs referred the eye clinic of a university-based hospital (2008-2016).RESULTS:
Forty-three diabetics (55 eyes) with mean age of 54.6 (SD12.5) years and 20 non-diabetics (24 eyes) with mean age of 57.5 (SD13.8) years were enrolled. Patients' survival was observed in 51% of diabetics and 70% of non-diabetics (P = .1). The mortality rate was 7.4 times (CI95% 1.85-29.96) higher in diabetic ROCM treated with non-liposomal amphotericin (P = .01). Exenteration did not significantly change the mortality rate in either group. Globe survival was 40% and 50% in diabetics and non-diabetics (P = 1), respectively. Vision survival was observed in 20% of diabetics and 37% of non-diabetics (P = .2).CONCLUSION:
Patients', globe and vision survivals were not different between diabetic and non-diabetic patients with ROCM. They were 51%, 40% and 20% in diabetic and 70%, 50% and 37% in non-diabetic ROCM.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doenças Orbitárias
/
Encefalopatias
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Complicações do Diabetes
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Diabetes Mellitus
/
Mucormicose
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article