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How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
Yaghoubi, Sajad; Najminejad, Hamid; Dabaghian, Mehran; Karimi, Mohammad Hossein; Abdollahpour-Alitappeh, Meghdad; Rad, Fariba; Mahi-Birjand, Motahareh; Mohammadi, Shiva; Mohseni, Fatemeh; Sobhani Lari, Mohammad; Teymouri, Gholam Hossein; Rigi Yousofabadi, Esmat; Salmani, Abbas; Bagheri, Nader.
Afiliação
  • Yaghoubi S; Department of Clinical Microbiology, Iranshahr University of Medical Sciences, Iranshahr, Iran.
  • Najminejad H; Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Dabaghian M; Research and Development Department, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran.
  • Karimi MH; Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Abdollahpour-Alitappeh M; Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, Iran.
  • Rad F; Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
  • Mahi-Birjand M; Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
  • Mohammadi S; Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran.
  • Mohseni F; Department of Biotechnology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Sobhani Lari M; Gerash University of Medical Sciences, Gerash, Iran.
  • Teymouri GH; Cellular and Molecular Biology Research Center, Larestan University of Medical Sciences, Larestan, Iran.
  • Rigi Yousofabadi E; Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran.
  • Salmani A; Department of Genetics, Iranshahr University of Medical Sciences, Iranshahr, Iran.
  • Bagheri N; Gerash University of Medical Sciences, Gerash, Iran.
IUBMB Life ; 72(7): 1286-1305, 2020 07.
Article em En | MEDLINE | ID: mdl-32196941
ABSTRACT
Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Microambiente Tumoral / Isquemia / Hipóxia / Neoplasias / Neovascularização Patológica Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Microambiente Tumoral / Isquemia / Hipóxia / Neoplasias / Neovascularização Patológica Idioma: En Ano de publicação: 2020 Tipo de documento: Article