5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
J UOEH
; 42(1): 27-34, 2020.
Article
em En
| MEDLINE
| ID: mdl-32213740
ABSTRACT
5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas. Although not a photosensitizer itself, 5-ALA is a prodrug that accumulates protoporphyrin IX (PpIX) in the mitochondria of glioma cells; PpIX acts as a photosensitizer. Fluorescence-guided resection for malignant gliomas has some pitfalls. Moreover, 5-ALA is not merely a fluorescence marker but has potential as a mitochondria-targeting drug for malignant glioma therapy. In this article, we review the literature related to 5-ALA, discuss the pitfalls of fluorescence-guided resection using 5-ALA for malignant gliomas, and describe the application of 5-ALA for malignant glioma therapy with personal opinions.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Cirurgia Assistida por Computador
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Fluorescência
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Glioma
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Ácido Aminolevulínico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article