Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.

Williams, Marc J; Zapata, Luis; Werner, Benjamin; Barnes, Chris P; Sottoriva, Andrea; Graham, Trevor A

Williams, Marc J; Zapata, Luis; Werner, Benjamin; Barnes, Chris P; Sottoriva, Andrea; Graham, Trevor A.

Afiliação

Williams MJ; Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Zapata L; Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, United States.
Werner B; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.
Barnes CP; Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Sottoriva A; Department of Cell and Developmental Biology, University College London, London, United Kingdom.
Graham TA; Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom.

Elife ; 92020 03 30.

Article em En | MEDLINE | ID: mdl-32223898

Assuntos

Evolução Clonal; Evolução Molecular; Aptidão Genética; Mutação; Esôfago/citologia; Humanos; Modelos Teóricos; Filogenia; Receptor Notch1/genética; Pele/citologia; Proteína Supressora de Tumor p53/genética

Palavras-chave

cancer evolution; computational biology; distribution of fitness effects; dn/ds; genetics; genomics; human; population genetics; somatic evolution; systems biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evolução Molecular / Aptidão Genética / Evolução Clonal / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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