Alterations in the nigrostriatal system following conditional inactivation of &#945;-synuclein in neurons of adult and aging mice.

Ninkina, Natalia; Tarasova, Tatiana V; Chaprov, Kirill D; Roman, Andrei Yu; Kukharsky, Michail S; Kolik, Larisa G; Ovchinnikov, Ruslan; Ustyugov, Aleksey A; Durnev, Andrey D; Buchman, Vladimir L

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice.

Ninkina, Natalia; Tarasova, Tatiana V; Chaprov, Kirill D; Roman, Andrei Yu; Kukharsky, Michail S; Kolik, Larisa G; Ovchinnikov, Ruslan; Ustyugov, Aleksey A; Durnev, Andrey D; Buchman, Vladimir L.

Afiliação

Ninkina N; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: ninkinan@cf.ac.uk.
Tarasova TV; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Chaprov KD; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Roman AY; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Kukharsky MS; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Kolik LG; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Ovchinnikov R; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation; Pirogov Russian National Research Medical University, Moscow, Russian Federation.
Ustyugov AA; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation.
Durnev AD; FSBI Research Zakusov Institute of Pharmacology (FSBI RZIP), Moscow, Russian Federation.
Buchman VL; School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), Moscow Region, Russian Federation. Electronic address: buchmanvl@cf.ac.uk.

Neurobiol Aging ; 91: 76-87, 2020 07.

Article em En | MEDLINE | ID: mdl-32224067

Assuntos

Envelhecimento/genética; Envelhecimento/patologia; Corpo Estriado/metabolismo; Corpo Estriado/patologia; Técnicas de Inativação de Genes; Doença de Parkinson/etiologia; Doença de Parkinson/genética; Substância Negra/metabolismo; Substância Negra/patologia; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; Família Aldeído Desidrogenase 1/genética; Família Aldeído Desidrogenase 1/metabolismo; Animais; Modelos Animais de Doenças; Dopamina/metabolismo; Regulação para Baixo; Expressão Gênica/genética; Camundongos Endogâmicos C57BL; Camundongos Knockout; Terapia de Alvo Molecular; Doença de Parkinson/terapia; Retinal Desidrogenase/genética; Retinal Desidrogenase/metabolismo; Transmissão Sináptica/genética

Palavras-chave

Conditional knockout; Dopamine turnover; Dopaminergic neurons; Parkinson's disease; Substantia nigra

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Envelhecimento / Substância Negra / Corpo Estriado / Alfa-Sinucleína / Técnicas de Inativação de Genes Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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