Progress in recent development of stereoselective synthesis of ß2-amino acid derivatives from ß-nitroacrylate derivatives.

ABSTRACT

The synthesis and properties of ß-amino acids have drawn considerable attention owing to their ubiquitous presence in naturally occurring products of biological importance. While ß3-amino acids can be readily prepared from α-amino acids via one-carbon homologation, the synthesis of ß2-amino acids generally requires multistep efforts. This review focuses on the recent advances in the synthesis of ß2-amino acids and their derivatives from substituted ß-nitropropionate analogues obtained from the stereoselective transformation of ß-nitroacrylates.