Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy.

Deshpande, Tushar; Li, Tingsong; Henning, Lukas; Wu, Zhou; Müller, Julia; Seifert, Gerald; Steinhäuser, Christian; Bedner, Peter

Deshpande, Tushar; Li, Tingsong; Henning, Lukas; Wu, Zhou; Müller, Julia; Seifert, Gerald; Steinhäuser, Christian; Bedner, Peter.

Afiliação

Deshpande T; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Li T; Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Henning L; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Wu Z; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Müller J; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Seifert G; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Steinhäuser C; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Bedner P; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.

Glia ; 68(10): 2136-2147, 2020 10.

Article em En | MEDLINE | ID: mdl-32240558

Assuntos

Astrócitos/metabolismo; Conexinas/deficiência; Epilepsia/induzido quimicamente; Epilepsia/metabolismo; Deleção de Genes; Ácido Caínico/toxicidade; Animais; Astrócitos/efeitos dos fármacos; Conexinas/genética; Epilepsia/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos

Palavras-chave

astrocyte; gap junction channels; hippocampal sclerosis; neurogenesis; status epilepticus; temporal lobe epilepsy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Deleção de Genes / Conexinas / Epilepsia / Ácido Caínico Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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