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Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity.
Zhu, Ming-Zhu; Li, Yi; Zhou, Jin-Chuan; Lu, Jing-Hui; Zhu, Rong-Xiu; Qiao, Ya-Nan; Zhang, Jiao-Zhen; Zong, Yan; Wang, Xue; Jin, Xue-Yang; Zhang, Ming; Chang, Wen-Qiang; Chen, Wang; Lou, Hong-Xiang.
Afiliação
  • Zhu MZ; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Li Y; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Zhou JC; School of Pharmacy, Linyi University, Linyi, 276000, China.
  • Lu JH; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Zhu RX; School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250010, China.
  • Qiao YN; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Zhang JZ; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Zong Y; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Wang X; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Jin XY; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Zhang M; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Chang WQ; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China.
  • Chen W; Vitamin D Research Institute, Shanxi University of Technology, Hanzhong, 723000, China.
  • Lou HX; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, China. Electronic address: louhongxiang@sdu.edu.cn.
Phytochemistry ; 174: 112341, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32240851
ABSTRACT
Eight undescribed terpenoids, namely, odongrossins A-H, together with two known terpenoids were isolated from Odontoschisma grosseverrucosum Stephani (Cephaloziaceae). Their structures were established based on NMR data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction measurements. Odongrossin A and odongrossin G displayed moderate anti-virulence activities against CDR1-and CDR2-efflux-pump-deficient Candida albicans DSY654. Further investigation of odongrossin A revealed that it inhibited adhesion and biofilm formation on C. albicans DSY654. The results regarding the transcription levels of genes demonstrated that odongrossin A could regulate the expression of genes that are associated with the virulence of C. albicans DSY654.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatófitas / Antifúngicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hepatófitas / Antifúngicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article