Terpenoids from the Chinese liverwort Odontoschisma grosseverrucosum and their antifungal virulence activity.
Phytochemistry
; 174: 112341, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32240851
ABSTRACT
Eight undescribed terpenoids, namely, odongrossins A-H, together with two known terpenoids were isolated from Odontoschisma grosseverrucosum Stephani (Cephaloziaceae). Their structures were established based on NMR data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction measurements. Odongrossin A and odongrossin G displayed moderate anti-virulence activities against CDR1-and CDR2-efflux-pump-deficient Candida albicans DSY654. Further investigation of odongrossin A revealed that it inhibited adhesion and biofilm formation on C. albicans DSY654. The results regarding the transcription levels of genes demonstrated that odongrossin A could regulate the expression of genes that are associated with the virulence of C. albicans DSY654.
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Base de dados:
MEDLINE
Assunto principal:
Hepatófitas
/
Antifúngicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article