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Inhibitory Activity of Scutellaria baicalensis Flavonoids against Tick-Borne Encephalitis Virus.
Leonova, G N; Shutikova, A L; Lubova, V A; Maistrovskaya, O S.
Afiliação
  • Leonova GN; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia. galinaleon41@gmail.com.
  • Shutikova AL; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
  • Lubova VA; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
  • Maistrovskaya OS; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
Bull Exp Biol Med ; 168(5): 665-668, 2020 Mar.
Article em En | MEDLINE | ID: mdl-32246365
We studied virus-inhibiting activity of Baikal skullcap (Scutellaria baicalensis) flavonoids against tick-borne encephalitis virus using various model schemes. The half-maximum cytotoxic concentration (CC50) for the plant extract was found (363.9±58.6 µg/ml). Based on the CC50 and IC50, selective index (SI) was calculated for viricidal (53.4), preventive (50.5), and direct antiviral actions (39.1) and for-intracellular replication of the virus (40.4). Suppression of virus reproduction ≥2.0 lg TCID50 was observed at extract concentration ≥5 µg/ml (viricidal effect), ≥11.2 µg/ml (preventive and direct antiviral effects), and ≥9 µg/ml (intracellular replication). Flavonoids of Baikal skullcap extract produced an in vitro inhibitory effect on tick-borne encephalitis virus due to their direct viricidal activity and direct inhibition of adsorption and intracellular replication of tick-borne encephalitis virus, which determines their value as highly effective antiviral drugs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Extratos Vegetais / Scutellaria baicalensis / Vírus da Encefalite Transmitidos por Carrapatos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Extratos Vegetais / Scutellaria baicalensis / Vírus da Encefalite Transmitidos por Carrapatos Idioma: En Ano de publicação: 2020 Tipo de documento: Article