Supraphysiological protection from replication stress does not extend mammalian lifespan.

Albers, Eliene; Avram, Alexandra; Sbroggio, Mauro; Fernandez-Capetillo, Oscar; Lopez-Contreras, Andres J

Albers, Eliene; Avram, Alexandra; Sbroggio, Mauro; Fernandez-Capetillo, Oscar; Lopez-Contreras, Andres J.

Afiliação

Albers E; Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Avram A; Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Sbroggio M; Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Fernandez-Capetillo O; Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Lopez-Contreras AJ; Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.

Aging (Albany NY) ; 12(7): 5612-5624, 2020 04 06.

Article em En | MEDLINE | ID: mdl-32253367

Assuntos

Quinase 1 do Ponto de Checagem/genética; Dano ao DNA; Longevidade/genética; Ribonucleosídeo Difosfato Redutase/genética; Animais; Quinase 1 do Ponto de Checagem/metabolismo; Replicação do DNA; Camundongos; Camundongos Transgênicos; Ribonucleosídeo Difosfato Redutase/metabolismo

Palavras-chave

DNA damage; aging; cancer; mouse models; replication stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribonucleosídeo Difosfato Redutase / Dano ao DNA / Quinase 1 do Ponto de Checagem / Longevidade Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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