Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry.
Hypertens Pregnancy
; 39(2): 103-116, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32255363
ABSTRACT
Objectives:
To investigate the association of uric acid gene polymorphisms and Pre-eclampsia.Methods:
637 women of African ancestry [280 controls, 357 pre-eclampsia (early-onset = 187, late-onset = 170]) retrospectively. The rs505802, rs1212986, and rs1014290 SNPs were genotyped from purified DNA using real-time PCR.Results:
CT genotype (rs505802) was higher in pre-eclampsia [Adjusted p = 0.028* OR (95% CI) = 1.73 (1.258-2.442)] and late-onset pre-eclampsia [Adjusted p = 0.027* OR (95% CI) = 1.75 (1.165-2.2628)] than controls. CT genotype (rs1014290) was higher in early-onset pre-eclampsia [Adjusted p-value = 0.040* OR (95% CI) = 1.60 (1.102-2.325)] than controls.Conclusion:
The genotyped rs505802 and rs1014290 are significantly associated with pre-eclampsia.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Ácido Úrico
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article