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The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey.
Zhang, Jinjia; Gao, Yiyang; Li, Yongze; Teng, Di; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Teng, Xiaochun; Shi, Xiaoguang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-An; Wang, Youmin; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Teng, Weiping; Shan, Zhongyan; Li, Jing.
Afiliação
  • Zhang J; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Gao Y; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Li Y; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Teng D; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Xue Y; Department of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China.
  • Yan L; Department of Endocrinology and Metabolism, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
  • Yang J; Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, China.
  • Yang L; Department of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, China.
  • Yao Y; Department of Endocrinology, Qinghai Provincial People's Hospital, Xining, China.
  • Ba J; Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
  • Chen B; Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Du J; Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
  • He L; Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital of Ningxia Medical University, Yinchuan, China.
  • Lai X; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Teng X; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Shi X; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Li Y; Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Chi H; Department of Endocrinology, Hohhot First Hospital, Hohhot, China.
  • Liao E; Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
  • Liu C; Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
  • Liu L; Department of Endocrinology and Metabolism, Fujian Institute of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China.
  • Qin G; Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
  • Qin Y; Department of Endocrine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Quan H; Department of Endocrinology, Hainan General Hospital, Haikou, China.
  • Shi B; Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Sun H; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tang X; Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.
  • Tong N; State Key Laboratory of Biotherapy, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
  • Wang G; Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, China.
  • Zhang JA; Department of Endocrinology, Shanghai University of Medicine & Health Science Affiliated Zhoupu Hospital, Shanghai, China.
  • Wang Y; Department of Endocrinology, The First Hospital of Anhui Medical University, Hefei, China.
  • Ye Z; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
  • Zhang Q; Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China.
  • Zhang L; Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
  • Zhu J; Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.
  • Zhu M; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
  • Teng W; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Shan Z; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Li J; Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Endocrinol (Lausanne) ; 11: 139, 2020.
Article em En | MEDLINE | ID: mdl-32256451
ABSTRACT

Purpose:

The expressions of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera of patients with autoimmune thyroid diseases (AITD). The relationship between thyroid autoantibodies and the occurrence of glucose and lipid metabolic disorders remains unclear. This study was performed to investigate the correlation between the presence of serum TPOAb/TgAb and those metabolic disorders in euthyroid general population.

Methods:

The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. A total of 17,964 euthyroid subjects including 5,802 males (4,000 with TPOAb-TgAb- and 1,802 with TPOAb+/TgAb+) and 12,162 females (8,000 with TPOAb-TgAb- and 4,162 with TPOAb+/TgAb+) were enrolled in this study. The blood glucose and lipid levels were compared between individuals with TPOAb-TgAb- and those with TPOAb+TgAb-, TPOAb-TgAb+, TPOAb+TgAb+.

Results:

Both fasting blood glucose (FBG) concentration and the proportion of individuals with impaired FBG (IFG) showed the decreased trends in TPOAb-TgAb+ males as compared with TPOAb-TgAb- men. There were significantly lower FBG and higher HDL-C levels as well as tendencies toward decreased incidences of IGT and hypertriglyceridemia in TPOAb-TgAb+ females when compared with TPOAb-TgAb- women. Binary logistic regression analysis further showed that serum TgAb single positivity in males was an independent protective factor for IFG with an OR of 0.691 (95% CI, 0.503-0.949). For females, serum TgAb single positivity was an independent protective factor for hypertriglyceridemia with an OR of 0.859 (95% CI, 0.748-0.987). Trend test showed that with the increase of serum TgAb level, there were significant decreases in the prevalence of IFG among the men with TSH ≤ 2.5 mIU/L and that of hypertriglyceridemia in the women, especially among non-obese females.

Conclusion:

Serum TgAb single positivity may imply a reduced risk of IFG in euthyroid men and that of hypertriglyceridemia in euthyroid women. The mechanisms for the independent protective roles of TgAb await further investigation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Tireoglobulina / Transtornos do Metabolismo de Glucose / Transtornos do Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autoanticorpos / Tireoglobulina / Transtornos do Metabolismo de Glucose / Transtornos do Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article