Bioinspired titanium coatings: self-assembly of collagen-alginate films for enhanced osseointegration.
J Mater Chem B
; 4(11): 1978-1986, 2016 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-32263075
ABSTRACT
Achieving long term osseointegration is fundamental to the development of successful bone implants. A key aspect for improving long term osseointegration on titania surfaces is to gain control of nano- and microscale features. The so called biological approach is applied here to modify the surface of titania by coating it with a self-assembled and chemically crosslinked biopolymer film made of alginate and collagen. The biofilm coated titania closely mimics the bone extracellular matrix in bio-morphology and mechanical properties. Biofilms are prepared using the layer by layer technique combined with carbodiimide chemistry to achieve a stable and compact structure. Alginate-collagen coatings display fibrillar morphology with an apparent fiber diameter of â¼50 nm and lengths ranging from a few hundred nanometers to â¼3 µm, mimicking therefore the extracellular matrix of the bone in fiber length and extent. Osteoblast MC3T3-E1 cells showed enhanced adhesion on the coated surface compared to the bare titania and a superior biological activity of the alginate-terminated coating that interfaces the cells in biological fluids.
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MEDLINE
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En
Ano de publicação:
2016
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Article