Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in <i>db/db</i> Mice.

Kang, Taewook; Boland, Brandon B; Jensen, Pia; Alarcon, Cristina; Nawrocki, Arkadiusz; Grimsby, Joseph S; Rhodes, Christopher J; Larsen, Martin R

Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.

Kang, Taewook; Boland, Brandon B; Jensen, Pia; Alarcon, Cristina; Nawrocki, Arkadiusz; Grimsby, Joseph S; Rhodes, Christopher J; Larsen, Martin R.

Afiliação

Kang T; Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark; The Danish Diabetes Academy, Odense, Denmark.
Boland BB; The Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637; Cardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Jensen P; Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
Alarcon C; The Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637.
Nawrocki A; Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.
Grimsby JS; Cardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Rhodes CJ; The Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes & Metabolism, University of Chicago, Chicago, Illinois 60637; Cardiovascular, Renal and Metabolic Disease, BioPharmaceuticals Research and Development, AstraZeneca Gaithersburg, Maryland 20878.
Larsen MR; Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. Electronic address: mrl@bmb.sdu.dk.

Mol Cell Proteomics ; 19(6): 971-993, 2020 06.

Article em En | MEDLINE | ID: mdl-32265294

Assuntos

Diabetes Mellitus Tipo 2/metabolismo; Hiperglicemia/metabolismo; Células Secretoras de Insulina/metabolismo; Insulina/metabolismo; Obesidade/metabolismo; Proinsulina/biossíntese; Proteoma/metabolismo; Animais; Glicemia/metabolismo; Diabetes Mellitus Tipo 2/genética; Modelos Animais de Doenças; Adesões Focais; Ontologia Genética; Glucose/metabolismo; Hiperglicemia/genética; Secreção de Insulina; Células Secretoras de Insulina/patologia; Sistema de Sinalização das MAP Quinases/genética; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/genética; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Proinsulina/metabolismo; Mapas de Interação de Proteínas; Processamento de Proteína Pós-Traducional; Proteoma/genética; Proteômica; Sistema Renina-Angiotensina; Ácidos Siálicos/metabolismo; Espectrometria de Massas em Tandem; Ubiquitinação

Palavras-chave

Diabetes; beta-granule biogenesis; glycoprotein pathways; glycoproteomics; insulin resistance; insulin secretory pathway; obesity; phosphoproteome; proinsulin biosynthesis; protein degradation; protein folding; protein synthesis; protein-protein interactions; signal transduction; unfolded protein response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proinsulina / Proteoma / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Hiperglicemia / Insulina / Obesidade Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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