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Autophagy suppresses breast cancer metastasis by degrading NBR1.
Marsh, Timothy; Debnath, Jayanta.
Afiliação
  • Marsh T; Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco , San Francisco, CA, USA.
  • Debnath J; Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco , San Francisco, CA, USA.
Autophagy ; 16(6): 1164-1165, 2020 06.
Article em En | MEDLINE | ID: mdl-32267786
Macroautophagy/autophagy plays complex, context-dependent roles in cancer. How autophagy governs the emergence of metastatic disease has been incompletely understood. We recently uncovered that genetic autophagy inhibition strongly attenuates primary tumor growth in mammary cancer models, yet paradoxically promotes spontaneous metastasis to the lung and enables the outgrowth of disseminated tumor cells (DTCs) into overt macro-metastases. Furthermore, at both primary and metastatic sites, genetic autophagy inhibition leads to the marked expansion of tumor cells exhibiting aggressive and pro-metastatic basal epithelial differentiation. These pro-metastatic effects of autophagy inhibition are due to the cytosolic accumulation of the autophagy cargo receptor NBR1 in autophagy-deficient tumor cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias da Mama Idioma: En Ano de publicação: 2020 Tipo de documento: Article