Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.
Bioorg Med Chem Lett
; 30(11): 127163, 2020 06 01.
Article
em En
| MEDLINE
| ID: mdl-32273214
ABSTRACT
Synthetic modifications have been made directly to the cyclic peptide core of polymyxin B, enabling the further understanding of structure activity relationships of this antimicrobial peptide. Such modified polymyxins are also substrates for enzymic hydrolysis, enabling the synthesis of a variety of semi-synthetic analogues, resulting in compounds with increased in vitro antibacterial activity.
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Base de dados:
MEDLINE
Assunto principal:
Polimixina B
/
Antibacterianos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article