[HMGB1: a link between innate and adaptive immunity]. / HMGB1: un lien entre inflammation septique et non septique.
Rev Francoph Lab
; 2009(417): 59-68, 2009 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-32288806
ABSTRACT
HMGB1 (High Mobility group box 1) protein was originally identified as a DNA-binding protein that functions as a structural co-factor. Recent works demonstrated that HMGB1 can be released outside the cell, upon immune activation or primary cell necrosis. In the extracellular space, HMGB1 acts as a potent soluble factor that coordinates cellular events that are crucial for the amplification of inflammation, establishment of early immune responses and tissue repair. However, extracellular HMGB1 also acts as a potent pro-inflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders.
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MEDLINE
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Fr
Ano de publicação:
2009
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Article