Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Varshavi, Dorna; Varshavi, Dorsa; McCarthy, Nicola; Veselkov, Kirill; Keun, Hector C; Everett, Jeremy R

Varshavi, Dorna; Varshavi, Dorsa; McCarthy, Nicola; Veselkov, Kirill; Keun, Hector C; Everett, Jeremy R.

Afiliação

Varshavi D; Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent, ME4 4TB, UK.
Varshavi D; Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent, ME4 4TB, UK.
McCarthy N; Horizon Discovery Ltd., Cambridge Research Park, 8100 Beach Dr, Waterbeach, Cambridge, CB25 9TL, UK.
Veselkov K; Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK.
Keun HC; Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, W12 ONN, UK.
Everett JR; Medway Metabonomics Research Group, University of Greenwich, Chatham Maritime, Kent, ME4 4TB, UK. j.r.everett@greenwich.ac.uk.

Metabolomics ; 16(4): 51, 2020 04 16.

Article em En | MEDLINE | ID: mdl-32300895

Assuntos

Neoplasias Colorretais/genética; Mutação; Proteínas Proto-Oncogênicas p21(ras)/genética; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Humanos; Metabolômica; Proteínas Proto-Oncogênicas p21(ras)/metabolismo; Células Tumorais Cultivadas

Palavras-chave

Colorectal cancer; KRAS; Metabolic profiling; Metabolomics; Metabonomics; Mutations; NMR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteínas Proto-Oncogênicas p21(ras) / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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