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Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.
Leger, Paul R; Hu, Dennis X; Biannic, Berenger; Bui, Minna; Han, Xinping; Karbarz, Emily; Maung, Jack; Okano, Akinori; Osipov, Maksim; Shibuya, Grant M; Young, Kyle; Higgs, Christopher; Abraham, Betty; Bradford, Delia; Cho, Cynthia; Colas, Christophe; Jacobson, Scott; Ohol, Yamini M; Pookot, Deepa; Rana, Payal; Sanchez, Jerick; Shah, Niket; Sun, Michael; Wong, Steve; Brockstedt, Dirk G; Kassner, Paul D; Schwarz, Jacob B; Wustrow, David J.
Afiliação
  • Leger PR; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Hu DX; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Biannic B; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Bui M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Han X; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Karbarz E; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Maung J; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Okano A; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Osipov M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Shibuya GM; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Young K; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Higgs C; Schrödinger, 120 West 45th Street, New York, New York 10036, United States.
  • Abraham B; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Bradford D; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Cho C; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Colas C; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Jacobson S; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Ohol YM; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Pookot D; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Rana P; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Sanchez J; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Shah N; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Sun M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Wong S; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Brockstedt DG; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Kassner PD; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Schwarz JB; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
  • Wustrow DJ; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.
J Med Chem ; 63(10): 5398-5420, 2020 05 28.
Article em En | MEDLINE | ID: mdl-32302140
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Peptidase 7 Específica de Ubiquitina / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Peptidase 7 Específica de Ubiquitina / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article