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Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
Salpini, Romina; Battisti, Arianna; Piermatteo, Lorenzo; Carioti, Luca; Anastasiou, Olympia E; Gill, Upkar S; Di Carlo, Domenico; Colagrossi, Luna; Duca, Leonardo; Bertoli, Ada; La Rosa, Katia Yu; Fabeni, Lavinia; Iuvara, Alessandra; Malagnino, Vincenzo; Cerva, Carlotta; Lichtner, Miriam; Mastroianni, Claudio M; De Sanctis, Giuseppe Maria; Paoloni, Maurizio; Marignani, Massimo; Pasquazzi, Caterina; Iapadre, Nerio; Parruti, Giustino; Vecchiet, Jacopo; Sarmati, Loredana; Andreoni, Massimo; Angelico, Mario; Grelli, Sandro; T Kennedy, Patrick; Verheyen, Jens; Aquaro, Stefano; Silberstein, Francesca Ceccherini; Perno, Carlo Federico; Svicher, Valentina.
Afiliação
  • Salpini R; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Battisti A; Barts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
  • Piermatteo L; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Carioti L; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Anastasiou OE; Institute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany.
  • Gill US; Barts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
  • Di Carlo D; Paediatric Clinical Research Center "Romeo and Enrica Invernizzi", University of Milan, Milan, Italy.
  • Colagrossi L; Microbiology and Virology Unit, University of Milan, Milan, Italy.
  • Duca L; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Bertoli A; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • La Rosa KY; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Fabeni L; Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" -IRCCS, Rome, Italy.
  • Iuvara A; Microbiology and Virology Unit, Tor Vergata University Hospital, Rome, Italy.
  • Malagnino V; Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
  • Cerva C; Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
  • Lichtner M; Public Health and Infectious Disease Department, "Sapienza" University, Rome, Italy.
  • Mastroianni CM; Public Health and Infectious Disease Department, "Sapienza" University, Rome, Italy.
  • De Sanctis GM; "Umberto I" University Hospital, Rome, Italy.
  • Paoloni M; Infectious Disease Unit, "S.S. Filippo e Nicola" Hospital, Avezzano, Italy.
  • Marignani M; Department of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
  • Pasquazzi C; Department of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
  • Iapadre N; "San Salvatore Hospital", L' Aquila, Italy.
  • Parruti G; Infectious Disease Unit, Pescara General Hospital, Pescara, Italy.
  • Vecchiet J; Department of Medicine and Science of Aging, Clinic of Infectious Diseases, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
  • Sarmati L; Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
  • Andreoni M; Infectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
  • Angelico M; Hepatology Unit, Tor Vergata University Hospital, Rome, Italy.
  • Grelli S; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • T Kennedy P; Microbiology and Virology Unit, Tor Vergata University Hospital, Rome, Italy.
  • Verheyen J; Barts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
  • Aquaro S; Institute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany.
  • Silberstein FC; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
  • Perno CF; Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Svicher V; Department of Oncology and Haemato-oncology, University of Milan, Milan, Italy.
Emerg Microbes Infect ; 9(1): 928-939, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32312174
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatite B Crônica / Antígenos de Superfície da Hepatite B Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Hepatite B Crônica / Antígenos de Superfície da Hepatite B Idioma: En Ano de publicação: 2020 Tipo de documento: Article