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Chitosan composite hydrogels cross-linked by multifunctional diazo resin as antibacterial dressings for improved wound healing.
Gao, Lilong; Zhang, Hui; Yu, Bing; Li, Wenlong; Gao, Fei; Zhang, Ke; Zhang, Hongbo; Shen, Youqing; Cong, Hailin.
Afiliação
  • Gao L; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Zhang H; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Yu B; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Li W; State Key Laboratory of Bio-Fibers and Eco-Textiles, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, China.
  • Gao F; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Zhang K; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Zhang H; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Shen Y; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
  • Cong H; Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao, China.
J Biomed Mater Res A ; 108(9): 1890-1898, 2020 09.
Article em En | MEDLINE | ID: mdl-32314510
ABSTRACT
Skin lesions and injuries can increase the risk of pathogen infections. Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing. Herein, we developed chitosan composite hydrogels cross-linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing. The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer. The resultant hydrogels (noted as DR-CCH) showed good stability at different DR concentrations in physiological buffers. The antibacterial assays showed the DR-CCH could inhibit and kill Escherichia coli and Staphylococcus aureus. What is more, our hydrogels could accelerate wound healing in vivo. The present study demonstrates this composite DR-CCH with trace zinc has potential for accelerated wound healing.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Hidrogéis / Quitosana / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bandagens / Cicatrização / Hidrogéis / Quitosana / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article