EGF receptor inhibitors comprehensively suppress hepatitis B virus by downregulation of STAT3 phosphorylation.

Gan, Chong J; Li, Wen F; Li, Chun N; Li, Ling L; Zhou, Wen Y; Peng, Xiao M.

Afiliação

Gan CJ; Center of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.
Li WF; Center of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.
Li CN; Center of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.
Li LL; Central Laboratory, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.
Zhou WY; Central Laboratory, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.
Peng XM; Center of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, 519000, China.

Biochem Biophys Rep ; 22: 100763, 2020 Jul.

Article em En | MEDLINE | ID: mdl-32322693

Palavras-chave

Antiviral therapy; Covalently closed circular DNA; EGF, epidermal growth factor; EGFR, epidermal growth factor inhibitor; Epidermal growth factor receptor inhibitor; GEq, genome equivalent; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; HNF3, hepatocyte nuclear factor 3; Hepatitis B virus; IFN, interferon; MTT, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; NAs, nucleotide/nucleoside analogues; NTCP, sodium taurocholate cotransporting polypeptide; PCR, polymerase chain reaction; SOCS3, suppressor of cytokine signaling 3; STAT3; STAT3, signal transduction and activators of transcription 3; cccDNA, covalently closed circular DNA

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article