Defective Regulation of Membrane TNF&#945; Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells.

Tyrinova, Tamara; Leplina, Olga; Mishinov, Sergey; Tikhonova, Marina; Dolgova, Evgeniya; Proskurina, Anastasiya; Stupack, Vyacheslav; Bogachev, Sergey; Ostanin, Alexander; Chernykh, Elena

Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells.

Tyrinova, Tamara; Leplina, Olga; Mishinov, Sergey; Tikhonova, Marina; Dolgova, Evgeniya; Proskurina, Anastasiya; Stupack, Vyacheslav; Bogachev, Sergey; Ostanin, Alexander; Chernykh, Elena.

Afiliação

Tyrinova T; Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.
Leplina O; Institute of Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.
Mishinov S; Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.
Tikhonova M; Novosibirsk Research Institute of Traumatology and Orthopedics them. Y.L.Tsivyana, 630091 Novosibirsk, Russia.
Dolgova E; Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.
Proskurina A; Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630099 Novosibirsk, Russia.
Stupack V; Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630099 Novosibirsk, Russia.
Bogachev S; Novosibirsk Research Institute of Traumatology and Orthopedics them. Y.L.Tsivyana, 630091 Novosibirsk, Russia.
Ostanin A; Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, 630099 Novosibirsk, Russia.
Chernykh E; Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.

Int J Mol Sci ; 21(8)2020 Apr 21.

Article em En | MEDLINE | ID: mdl-32326230

Assuntos

Membrana Celular/metabolismo; Citotoxicidade Imunológica; Células Dendríticas/imunologia; Células Dendríticas/metabolismo; Glioblastoma/etiologia; Glioblastoma/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Biomarcadores; Linhagem Celular Tumoral; Suscetibilidade a Doenças; Expressão Gênica; Glioblastoma/patologia; Humanos; Interleucina-2/metabolismo; Interleucina-2/farmacologia; Células Tumorais Cultivadas; Fator de Necrose Tumoral alfa/genética

Palavras-chave

TACE/ADAM-17; TNFα; dendritic cells; glioblastoma; granule-dependent cytotoxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Dendríticas / Membrana Celular / Fator de Necrose Tumoral alfa / Glioblastoma / Citotoxicidade Imunológica Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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