Anti-biofilm activity of a novel pit and fissure self-adhesive sealant modified with metallic monomers.
Biofouling
; 36(3): 245-255, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-32326753
ABSTRACT
Dental plaque is a biofilm composed of a complex oral microbial community. The accumulation of plaque in the pit and fissures of dental elements often leads to the development of tooth decay (dental caries). Here, potent anti-biofilm materials were developed by incorporating zinc methacrylates or di-n-butyl-dimethacrylate-tin into the light-curable sealant and their physical, mechanical, and biological properties were evaluated. The data revealed that 5% di-n-butyl-dimethacrylate-tin (SnM 5%) incorporated sealant showed strong anti-biofilm efficacy against various single-species (Streptococcus mutans or Streptococcus oralis or Candida albicans) and S. mutans-C. albicans cross-kingdom dual-species biofilms without either impairing the mechanical properties of the sealant or causing cytotoxicities against mouse fibroblasts. The findings indicate that the incorporation of SnM 5% in the experimental pit and fissure self-adhesive sealant may have the potential to be part of current chemotherapeutic strategies to prevent the formation of cariogenic oral biofilms that cause dental caries.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selantes de Fossas e Fissuras
/
Zinco
/
Adesivos
/
Biofilmes
/
Cárie Dentária
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article