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TGF-ß1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Okina, Yoshinori; Sato-Matsubara, Misako; Matsubara, Tsutomu; Daikoku, Atsuko; Longato, Lisa; Rombouts, Krista; Thanh Thuy, Le Thi; Ichikawa, Hiroshi; Minamiyama, Yukiko; Kadota, Mitsutaka; Fujii, Hideki; Enomoto, Masaru; Ikeda, Kazuo; Yoshizato, Katsutoshi; Pinzani, Massimo; Kawada, Norifumi.
Afiliação
  • Okina Y; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Sato-Matsubara M; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan; Endowed Laboratory of Synthetic Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Matsubara T; Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Daikoku A; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Longato L; Regenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom.
  • Rombouts K; Regenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom.
  • Thanh Thuy LT; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Ichikawa H; Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0321, Japan.
  • Minamiyama Y; Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.
  • Kadota M; Laboratory for Phyloinformatics, RIKEN Center for Biosystems Dynamics Research, Hyogo 650-0047, Japan.
  • Fujii H; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Enomoto M; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Ikeda K; Department of Anatomy and Regenerative Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Yoshizato K; Endowed Laboratory of Synthetic Biology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.
  • Pinzani M; Regenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Hospital, London NW3 2PF, United Kingdom.
  • Kawada N; Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan. Electronic address: kawadanori@med.osaka-cu.ac.jp.
J Hepatol ; 73(4): 882-895, 2020 10.
Article em En | MEDLINE | ID: mdl-32330605
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Proteína Smad3 / Fator de Crescimento Transformador beta1 / Células Estreladas do Fígado / Hepatopatia Gordurosa não Alcoólica / NADPH Oxidase 4 / Citoglobina Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / Proteína Smad3 / Fator de Crescimento Transformador beta1 / Células Estreladas do Fígado / Hepatopatia Gordurosa não Alcoólica / NADPH Oxidase 4 / Citoglobina Idioma: En Ano de publicação: 2020 Tipo de documento: Article