A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression.
Cell Death Dis
; 11(4): 282, 2020 04 24.
Article
em En
| MEDLINE
| ID: mdl-32332696
ABSTRACT
Mixed-lineage kinase domain-like protein (MLKL) is known as the terminal executor of necroptosis. However, its function outside of necroptosis is still not clear. Herein, we demonstrate that MLKL promotes vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells (EC). MLKL deficiency suppresses the expression of these adhesion molecules, thereby reducing EC-leukocyte interaction in vitro and in vivo. Mechanistically, we show that MLKL interacts with RBM6 to promote the mRNA stability of adhesion molecules. In conclusion, this study identified a novel role of MLKL in regulating endothelial adhesion molecule expression and local EC-leukocyte interaction during acute inflammation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Células Endoteliais
/
Necrose
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article