Sugar-cane bagasse cellulose-based scaffolds promote multi-cellular interactions, angiogenesis and reduce inflammation for skin tissue regeneration.
Int J Biol Macromol
; 157: 296-310, 2020 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-32339588
ABSTRACT
In a previous article, we reported on the physico-chemical properties of cellulose-based scaffolds derived from sugar-cane bagasse and their preliminary in vitro assessment. In view of skin tissue regeneration, we here present our findings of an extensive in vitro testing of these scaffolds using key cells involved in the wound healing cascade namely fibroblasts, keratinocytes, endothelial cells and macrophages either singly or in various combinations to mimic in vivo conditions. Inflammation was quantified using TNF-α. In vivo biocompatibility as well as wound healing potential of the scaffolds was demonstrated using Wistar rats. Finally, we discuss the effect of curcumin-loaded scaffolds on inflammation and angiogenesis in vitro and in vivo. Nanosilica extracted from sugar-cane bagasse ash was also loaded in the scaffolds and its effect on biological response was assessed.
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Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Comunicação Celular
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Celulose
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Neovascularização Fisiológica
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Saccharum
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Alicerces Teciduais
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article