Knockout of macrophage migration inhibitory factor accentuates side-stream smoke exposure-induced myocardial contractile dysfunction through dysregulated mitophagy.

Wang, Shuyi; Chen, Xu; Zeng, Biru; Xu, Xihui; Chen, Huaguo; Zhao, Ping; Hilaire, Michelle L; Bucala, Richard; Zheng, Qijun; Ren, Jun

Wang, Shuyi; Chen, Xu; Zeng, Biru; Xu, Xihui; Chen, Huaguo; Zhao, Ping; Hilaire, Michelle L; Bucala, Richard; Zheng, Qijun; Ren, Jun.

Afiliação

Wang S; Department of Emergency, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai 200072, China; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie 82071, WY USA. Electronic address: swang7@uwyo.edu.
Chen X; Department of Cardiovascular Surgery, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
Zeng B; Department of Cardiovascular Surgery, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
Xu X; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie 82071, WY USA.
Chen H; Department of Emergency, Shanghai Tenth People's Hospital, School of Medicine Tongji University, Shanghai 200072, China.
Zhao P; Department of Cardiovascular Surgery, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
Hilaire ML; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie 82071, WY USA.
Bucala R; Department of Medicine, Yale School of Medicine, New Haven 06520, CT USA.
Zheng Q; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie 82071, WY USA; Department of Cardiovascular Surgery, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen 518020, China. Electronic address: zhengqj@fmmu.edu.cn.
Ren J; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie 82071, WY USA; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University, Shanghai 200032, China. Electronic address: jren_aldh2@outlook.com.

Pharmacol Res ; 157: 104828, 2020 07.

Article em En | MEDLINE | ID: mdl-32339783

Assuntos

Oxirredutases Intramoleculares/deficiência; Fatores Inibidores da Migração de Macrófagos/deficiência; Mitocôndrias Cardíacas/metabolismo; Mitofagia; Contração Miocárdica; Miócitos Cardíacos/metabolismo; Poluição por Fumaça de Tabaco; Disfunção Ventricular Esquerda/metabolismo; Função Ventricular Esquerda; Animais; Sinalização do Cálcio; Modelos Animais de Doenças; Fibrose; Oxirredutases Intramoleculares/genética; Fatores Inibidores da Migração de Macrófagos/genética; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mitocôndrias Cardíacas/ultraestrutura; Miócitos Cardíacos/ultraestrutura; Disfunção Ventricular Esquerda/etiologia; Disfunção Ventricular Esquerda/patologia; Disfunção Ventricular Esquerda/fisiopatologia

Palavras-chave

Autophagy; Cardiomyocyte; MIF; Mitophagy; Smoke exposure

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluição por Fumaça de Tabaco / Função Ventricular Esquerda / Fatores Inibidores da Migração de Macrófagos / Disfunção Ventricular Esquerda / Oxirredutases Intramoleculares / Miócitos Cardíacos / Mitofagia / Mitocôndrias Cardíacas / Contração Miocárdica Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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