Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists.

Vasile, Silvana; Hallberg, Anders; Sallander, Jessica; Hallberg, Mathias; Åqvist, Johan; Gutiérrez-de-Terán, Hugo

Vasile, Silvana; Hallberg, Anders; Sallander, Jessica; Hallberg, Mathias; Åqvist, Johan; Gutiérrez-de-Terán, Hugo.

Afiliação

Vasile S; Sweden and Science for Life Laboratory, Department of Cell and Molecular Biology, BMC (H.G.T.), Biomedical Centre (BMC), Uppsala University, P.O. BOX 596, SE-751 24 Uppsala, Sweden.
Hallberg A; Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, BMC, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
Sallander J; Sweden and Science for Life Laboratory, Department of Cell and Molecular Biology, BMC (H.G.T.), Biomedical Centre (BMC), Uppsala University, P.O. BOX 596, SE-751 24 Uppsala, Sweden.
Hallberg M; The Beijer Laboratory, Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, BMC, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden.
Åqvist J; Sweden and Science for Life Laboratory, Department of Cell and Molecular Biology, BMC (H.G.T.), Biomedical Centre (BMC), Uppsala University, P.O. BOX 596, SE-751 24 Uppsala, Sweden.
Gutiérrez-de-Terán H; Sweden and Science for Life Laboratory, Department of Cell and Molecular Biology, BMC (H.G.T.), Biomedical Centre (BMC), Uppsala University, P.O. BOX 596, SE-751 24 Uppsala, Sweden.

Biomolecules ; 10(4)2020 04 23.

Article em En | MEDLINE | ID: mdl-32340100

Assuntos

Angiotensina II/farmacologia; Peptídeos/farmacologia; Peptidomiméticos/farmacologia; Receptor Tipo 2 de Angiotensina/agonistas; Angiotensina II/química; Sítios de Ligação; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Peptídeos/química; Peptidomiméticos/química; Receptor Tipo 1 de Angiotensina/agonistas; Receptor Tipo 1 de Angiotensina/química; Receptor Tipo 2 de Angiotensina/química; Termodinâmica

Palavras-chave

AT2R agonist; G-protein coupled receptor (GPCR); angiotensin; free energy perturbation (FEP); molecular dynamics (MD); peptidomimetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Angiotensina II / Receptor Tipo 2 de Angiotensina / Peptidomiméticos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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