An Affibody Molecule Is Actively Transported into the Cerebrospinal Fluid via Binding to the Transferrin Receptor.

Meister, Sebastian W; Hjelm, Linnea C; Dannemeyer, Melanie; Tegel, Hanna; Lindberg, Hanna; Ståhl, Stefan; Löfblom, John

Meister, Sebastian W; Hjelm, Linnea C; Dannemeyer, Melanie; Tegel, Hanna; Lindberg, Hanna; Ståhl, Stefan; Löfblom, John.

Afiliação

Meister SW; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Hjelm LC; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Dannemeyer M; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Tegel H; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Lindberg H; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Ståhl S; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.
Löfblom J; Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, AlbaNova University Centre, SE-106 91 Stockholm, Sweden.

Int J Mol Sci ; 21(8)2020 Apr 23.

Article em En | MEDLINE | ID: mdl-32340383

Assuntos

Barreira Hematoencefálica/metabolismo; Receptores da Transferrina/metabolismo; Proteínas Recombinantes de Fusão/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Transporte Biológico; Desenho de Fármacos; Citometria de Fluxo; Humanos; Camundongos; Modelos Moleculares; Conformação Molecular; Permeabilidade; Ligação Proteica; Domínios e Motivos de Interação entre Proteínas; Transporte Proteico; Proteínas Recombinantes de Fusão/química; Proteínas Recombinantes de Fusão/farmacocinética; Relação Estrutura-Atividade

Palavras-chave

affibody molecules; bloodbrain barrier; neurodegenerative disorders; receptor-mediated transcytosis; transferrin receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores da Transferrina / Proteínas Recombinantes de Fusão / Barreira Hematoencefálica Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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