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Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.
Han, Guiyan; Liu, Na; Li, Chenglan; Tu, Jie; Li, Zhuang; Sheng, Chunquan.
Afiliação
  • Han G; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
  • Liu N; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
  • Li C; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
  • Tu J; School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
  • Li Z; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
  • Sheng C; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
J Med Chem ; 63(10): 5341-5359, 2020 05 28.
Article em En | MEDLINE | ID: mdl-32347094
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azóis / Candidíase / Farmacorresistência Fúngica / Descoberta de Drogas / Inibidores de Histona Desacetilases / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azóis / Candidíase / Farmacorresistência Fúngica / Descoberta de Drogas / Inibidores de Histona Desacetilases / Esterol 14-Desmetilase / Inibidores de 14-alfa Desmetilase Idioma: En Ano de publicação: 2020 Tipo de documento: Article